Co-Immunoprecipitation & Protein Binding

Name Cat# Price (1ml, USD) Add to cart
MagVigen™ – PD-L1 On-Bead ELISA Kit
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KE7101 $560
for 96 assays
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MagVigen™ – HER2 On-Bead ELISA Kit
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KE7102 $560
for 96 assays
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MagVigen™ – EGFR On-Bead ELISA Kit
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KE7103 $560
for 96 assays
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MagVigen™ – Protein A conjugates
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21003 $190 PayPal
MagVigen™ – Protein A Kit
Product Sheet
K21003 $220 PayPal
MagVigen™ – Protein G conjugates
Product Sheet
21004 $211 PayPal
MagVigen™ – Protein G Kit
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K21004 $240 PayPal
MagVigen™ – Streptavidin, protein capture
Product Sheet
21005P
MagVigen™ – Streptavidin, protein capture kit
Product Sheet
K21005P

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MagVigen™ – Anti-rabbit IgG conjugates
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21006 $211 PayPal
MagVigen™ – Anti-rabbit IgG Kit
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K21006 $240 PayPal
MagVigen™ -Anti-mouse IgG conjugates
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21007 $210 PayPal
MagVigen™ -Anti-mouse IgG Kit
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K21007 $240 PayPal
MagVigen™ – Protein A/G conjugates
Product Sheet
21009
MagVigen™ – protein A/G kit
Product Sheet
K21009
Washing Buffer (10X) A20001 $20(15ml) PayPal
Elution Buffer A20002 $20(15ml) PayPal
MagVigen™ – customize 21008 Contact Us

Citations:

  1. Combined functions of two RRMs in Dead-end1 mimic helicase activity to promote nanos1 translation in the germline.
  2. Structural basis of RIP2 activation and signaling
  3. Mechanisms of RNA sorting into exosomes

Discover Elusive Interacting Proteins!

MagVigen™ for Co-Immunoprecipitation

  • Smaller beads
  • Low nonspecific binding
  • Higher binding capacity (6x higher)
  • Highly biocompatible surfaces
  • Less steric hindrance and better accessibility to epitopes
  • Optimal surface chemistry
  • High throughput automation

MagVigen nanobeads plus sign interacting Protein A and Protein B molecules right arrow Protein A and Protein B bound with MagVigen beads dynamic interactions discovered between proteins using MagVigen co_ip

Figure 1. Dynamic interactions between Protein A and Protein B were detected by co-immunoprecipitation using MagVigen™ nanobeads. Such interactions were not seen using conventional magnetic beads.

big conventional magnetic beads

Figure 2. Conventioal magnetic beads may present more steric hindrance and unideal chemistry hence not capturing elusive molecular/protein interactions.

biotinylated-mouse-igg-capture-magvigen-streptavidin-(2mg/ml)-vs-dynabeads-myone-streptavidin-(10mg/ml)

Figure 3. Two Lots of MagVigen™ Streptavidin (2mg/mL) and Dynabeads MyOne Streptavidin (10mg/mL) were used to capture 1µg of biotinylated mouse IgG. The amount of uncaptured biotinylated mouse IgG was determined by ELISA. The percentage of captured biotinylated mouse IgG was plotted. MagVigen™ beads showed an antibody binding capacity of 50µg/mg compared to 12µg/mg for Dynabeads.

capture-antibody-conjugated-magvigen-streptavidin-beads-vs-dynabeads-myone-vs-merck-beads

Figure 4. Capture antibody conjugated MagVigen™ Streptavidin beads (20 µg), Dynabeads MyOne (30 µg) and Merck beads (30 µg) were used in ELISA assay following a standard protocol to detect HBV antigen HBsAg. Bead pellets were reconstituted in 100µl of PBS in the end and 5µl were used to develop color.

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