NVIGEN X™
Precision Medicine Biomarker Profiling
NGS & Multiomics

Magnetic Nanoparticle Enabled Highly Sensitive and Accurate Assays

High Yield Sample Preparation

  • Precision
  • Rare Targets
  • Automation Ready
  • Screening
  • Monitoring & Treatment Guidance

Comprehensive and Customizable
Cancer Gene Panel

AKT1 ALK* AR BRAF* BRCA1* BRCA2* CD274* EGFR*
ERBB2* ESR1* FGFR1* FGFR2* FGFR3* KRAS* MET* MLH1
MSH2 MSH6 NRAS NTRK1* NTRK2* NTRK3* PALB2 PDGFRA*
PIK3CA* PMS2 PTEN RB1 RET* ROS1* STK11 TP53*
ATM BARD1 BRIP1 CDH1 CHEK2 CTNNB1 EPCAM EZH2
ERBB3 FOXA1 GATA3 IDH1 MAP3K1 MYC MUTYH NF1
RAD51C RAD51D KIT* CDK12 NOTCH1 RPTOR CCND1 MDM2
IGF1R CDK4 CDK6 PPP2R2A* TSC1 JAK2* SMO Other

* Genes with FDA approved therapeutic products

Robust Workflow

  • Blood, Tissue, Saliva, Pleural Fluid and More
  • Compatible with Multiple Sequencers
  • High NGS Data Efficiency
  • Consistent Results

High Sensitivity and Specificity

NVIGEN X-
Standard Depth

VAF Sensitivity Specificity
0.1-0.25% > 60-80% 95-99%
0.25-0.5% > 90-95% 99%
> 0.5% 99% 99%

NVIGEN X-
High Depth

VAF Sensitivity Specificity
0.1-0.25% > 90-95% 95-99%
0.25-0.5% > 97-99% 99%
> 0.5% 99% 99%

Cleaner and More Accurate NGS Data

Left: NVIGEN X assay for 17 patients and 14 normal human samples shows the assay enables clear differentiation between patients and normal humans. Right: Two sample t-test from SciPy library shows statistical significance (p=1.73E-05) to differentiate between breast cancer patients and normal humans based on gene alterations detected with NVIGEN X assay.

Integrated Protein Biomarker Analyses

  • Magnetic Nanoparticle Enabled
  • Streamlined Workflow
  • Variable Multiplex Formats
  • Customizable Protein Markers: PD-L1, Her2, EGFR, Trop-2, CEA, CA15-3, TNF-alpha, IL-6…

CTC Capture and Analyses in Parallel
With ctDNA

  • Magnetic CTC Capture for DNA/RNA/Protein Analyses
  • Clinically Significant Complementary and Confirmative Information
  • Screening, Surveillance and Treatment Guidance

Automation Ready

  • Streamlined Sample Process
  • High Consistency
  • Program Support
  • Personalized Cancer Care
  • Aging and Neurodegenerative Diseases
  • High Sensitivity for Rare Target Identification and Drug Development
  • Complex Biomarker Discovery
  • Single Cell or Intracellular Molecules

Cancer Patient Case Study

  • Benchmark Validation
  • Serial Sampling and Monitoring
  • Treatment Guidance
  • Life Saving

Save Lives with NVIGEN

Enhanced Disease Understanding

Preventative & Curative Health Care

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